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  • Title: Exercising muscle does not produce hypoxanthine in adenylate deaminase deficiency.
    Author: Patterson VH, Kaiser KK, Brooke MH.
    Journal: Neurology; 1983 Jun; 33(6):784-6. PubMed ID: 6682523.
    Abstract:
    The failure of forearm exercise to increase plasma hypoxanthine in subjects with adenylate deaminase deficiency confirms this enzyme's role in hypoxanthine production by normal forearm exercise. The conversion of adenosine monophosphate (AMP) to hypoxanthine may reflect an alternative method of adenosine triphosphate (ATP) regeneration in working muscle.
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