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  • Title: The anxiogenic action of Ro 5-4864 is reversed by phenytoin.
    Author: File SE, Lister RG.
    Journal: Neurosci Lett; 1983 Jan 31; 35(1):93-6. PubMed ID: 6682534.
    Abstract:
    Ro 5-4864, a selective ligand for the benzodiazepine micromolar and peripheral receptors, had a significant dose-related (5-20 mg/kg) anxiogenic action in the social interaction test of anxiety. This anxiogenic effect was reversed by phenytoin (10 mg/kg), a ligand for the micromolar receptors, but unaffected by the isoquinoline PK 11195 (10 mg/kg), a ligand for the peripheral receptors.
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