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Title: Expression of the fragile site Xq27 in fibroblasts. I. Detection of fra(X)(q27) in fibroblast clones from males with X-linked mental retardation. Author: Steinbach P, Barbi G, Baur S, Wiedenmann A. Journal: Hum Genet; 1983; 63(4):404-5. PubMed ID: 6683244. Abstract: Twelve fibroblast clones from two males with X-linked mental retardation expressed the fragile site Xq27 in 3%-38% of metaphases analyzed. The number of in vitro doublings during the cloning procedure had no evident influence on the induction of fragile X expression. The variability of fragile X expression seems to depend on cell properties acquired during culture rather than on properties originally inherent in the cells.[Abstract] [Full Text] [Related] [New Search]