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  • Title: A study of intestinal copper-binding proteins in mottled mice.
    Author: Crane IJ, Hunt DM.
    Journal: Chem Biol Interact; 1983 Jul 01; 45(1):113-24. PubMed ID: 6683596.
    Abstract:
    The substantial retention of Cu2+ and to a lesser extent Zn2+, in the gut mucosa of neonatal MO mutant mice is largely associated with a low molecular weight protein tentatively identified as metallothionein. [35S]Cysteine incorporation into this protein in mutant mice is elevated, indicating that Cu2+ retention in the gut is associated with an increase in the synthesis of metallothionein. The high Cu2+ levels of mutant gut tissue decline rapidly with age to reach an approximately normal level by 24 days of age; this decline cannot be prevented by dietary supplementation and it is suggested that gut 'closure' and consequent reduced uptake by pinocytosis are important factors in this decline.
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