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  • Title: Yohimbine exacerbates and clonidine attenuates acute morphine withdrawal in rats.
    Author: Dwoskin LP, Neal BS, Sparber SB.
    Journal: Eur J Pharmacol; 1983 Jun 03; 90(2-3):269-73. PubMed ID: 6683657.
    Abstract:
    The involvement of alpha 2-noradrenergic receptors in the expression of opiate withdrawal was studied using an operant behavioral model of acute morphine dependence. Clonidine, an alpha 2-agonist, attenuated and yohimbine, an alpha 2-antagonist, exacerbated the naloxone-induced suppression of fixed ratio 15 responding in rats pretreated several hours earlier with a single, moderate dose of morphine. These data indicate that the alpha 2-agonist action of clonidine is responsible for its amelioration of withdrawal symptoms. It also validates the acute dependence model for studying the pharmacology of opiates and associated adaptive processes.
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