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  • Title: Structure-activity relationships in a series of anti-inflammatory N-arylanthranilic acids.
    Author: Kaltenbronn JS, Scherrer RA, Short FW, Jones EM, Beatty HR, Saka MM, Winder CV, Wax J, Williamson WR.
    Journal: Arzneimittelforschung; 1983; 33(4A):621-7. PubMed ID: 6683967.
    Abstract:
    A large series of N-arylanthranilic acids has been prepared. Many of these compounds show high anti-inflammatory activity as measured by the anti-UV-erythema test. From this series have come the clinically useful non-steroidal anti-inflammatory agents, flufenamic acid (Arlef), mefenamic acid (Ponstel), and the latest and most potent agent, N-(2,6-dichloro-m-tolyl)anthranilic acid (meclofenamic acid, Meclomen = the sodium salt). The structure-activity relationships of this series is discussed and a graphical representation is presented which allows the prediction of activity of new agents.
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