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  • Title: Study of the effects of oral administration of CDP-choline on EEG changes and lethality induced by epidural compression in the anaesthetised cat.
    Author: Algate DR, Beard DJ, Sacristán A, Ortiz JA, Davies JE.
    Journal: Arzneimittelforschung; 1983; 33(7A):1013-6. PubMed ID: 6684452.
    Abstract:
    The effects of repeated oral administration of cytidine diphosphate choline (CDP-choline, citicoline, Somazina) and vehicle on the EEG changes induced by epidural brain compression have been studied in the anaesthetised cat. The effects on arterial pressure and heart rate were also monitored. CDP-Choline-treated cats exhibited a statistically significant increase in resistance to the effects of mechanical compression of the brain when compared with the vehicle-treated group. In addition the onset of abnormal EEG waveforms occurred at greater levels of brain compression in drug-treated cats. CDP-Choline also imparted protection against the cardiovascular and respiratory effects of brain compression; animals were apparently less susceptible to cardiac and respiratory failure under the influence of the test compound. A statistically significant protection against the lethal effects of epidural compression was also noted in CDP-choline treated cats. It may be concluded that repeated oral treatment with CDP-Choline provides an apparent protection against the effects of acute mechanical compression of the brain.
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