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  • Title: High-resolution autoradiography in mouse brain and cerebellum 10 days after radiolabelled CDP-choline administration.
    Author: Romero A, Serratosa J, Sacristán A, Ortiz JA.
    Journal: Arzneimittelforschung; 1983; 33(7A):1058-60. PubMed ID: 6684467.
    Abstract:
    A dose of 5 microCi of cytidine diphosphate choline (CDP-choline, citicoline, Somazina) (methyl 14C) was administered to mice. Animals were sacrificed 10 days after administration and their brain and cerebellum isolated for autoradiography and electron microscopy. Sections were prepared in such a manner that a general topographic assignment of radioactivity distribution to different layers and brain structures could be made. Regarding the intracellular distribution of the different cellular types observed, Purkinje's cells exhibited in a density of focus emission higher than the others.
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