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  • Title: Newer formazans and tetrazolium indoles as potential CNS-active agents.
    Author: Sathi G, Gujrati VR, Nath C, Agarwal JC, Bhargava KP, Shanker K.
    Journal: Arzneimittelforschung; 1983; 33(9):1218-21. PubMed ID: 6685502.
    Abstract:
    Some new 2-aryl-5-(3'-indole)-3'-substituted phenyl tetrazolium bromide/iodide salts (IV) were synthesized by the oxidation of 1-aryl-3-(3'-indole)-5-substituted phenyl fromazans (III). These compounds III and IV were evaluated for their monoamine oxidase (MAO) inhibitory activity in vitro and various CNS activities in vivo. Several compounds exhibited promising CNS activities, III-b being the most active member of the present series showing marked antidepressant and MAO inhibitory activities and having low toxicity.
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