These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Plasma levels of mepindolol in healthy volunteers after oral doses of mepindolol sulphate.
    Author: Krause W, Schwartzkopff W.
    Journal: Arzneimittelforschung; 1983; 33(9):1306-7. PubMed ID: 6685513.
    Abstract:
    Three groups of healthy volunteers were given oral doses of 5, 10 and 20 mg, respectively, of the beta-receptor blocking drug mepindolol sulphate (Corindolan). Plasma levels of the active compound mepindolol were measured by means of a sensitive and specific HPLC method. Mepindolol was rapidly absorbed reaching maximum concentrations of 21 +/- 7 ng/ml (5 mg), 47 +/- 23 ng/ml (10 mg) and 54 +/- 29 ng/ml (20 mg) 1--3 h after administration. The AUC ratio of the three doses studied was 1 : 1.9 : 3.0 suggesting incomplete absorption in the 20 mg group. The biological half-life of the drug was calculated to be 3--4 h, independently of the dose administered.
    [Abstract] [Full Text] [Related] [New Search]