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  • Title: [Cimetidine in the treatment of duodenal ulcer (author's transl)].
    Author: Peter P, Kiene K, Gonvers JJ, Pelloni S, Weber K, Sonnenberg A, Schmitz H, Richter O, Hofstetter JR, Blum AL, Strohmeyer G.
    Journal: Dtsch Med Wochenschr; 1978 Jul 21; 103(29):1163-6. PubMed ID: 668553.
    Abstract:
    In a double-blind trial of patients with duodenal ulcer at three centres the healing rate after a four-week course of treatment (1 g cimetidine daily) was 79% (30 out of 38 patients), compared with 58% (23 out of 40 patients) on placebos. Cimetidine did not effect subjective symptoms or the need for antacids to relieve pain, except for a minor beneficial effect on diurnal ulcer symptoms during the second week of treatment. Results of long-term administration suggest that cimetidine at 400 mg daily prevent s relapses, but the possibility of an increased relapse rate after cimetidine withdrawal can not as yet be excluded.
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