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  • Title: Anxiogenic action of a convulsant benzodiazepine: reversal by chlordiazepoxide.
    Author: File SE, Pellow S.
    Journal: Brain Res; 1983 Nov 14; 278(1-2):370-2. PubMed ID: 6685556.
    Abstract:
    Ro5-3663, a convulsant benzodiazepine and a ligand for CNS picrotoxin sites, but not for benzodiazepine sites, had a significant dose-related (2 and 4 mg/kg) anxiogenic action in the social interaction test of anxiety. This anxiogenic effect was reversed by chlordiazepoxide (5 mg/kg).
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