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  • Title: Small bowel deposition of crystals associated with the use of clofazimine (Lamprene) in the treatment of prurigo nodularis.
    Author: Belaube P, Devaux J, Pizzi M, Boutboul R, Privat Y.
    Journal: Int J Lepr Other Mycobact Dis; 1983 Sep; 51(3):328-30. PubMed ID: 6685693.
    Abstract:
    A 46-year-old woman with widespread prurigo nodularis was treated with 300 mg clofazimine a day for six months. Ten months after stopping the drug she complained of weight loss and gastrointestinal side effects which were shortly improved by a gluten-free diet, but relapsed one year later. At laparotomy, all tissues were stained bright orange-yellow, and histological examination showed crystals deposited in the chorion of intestinal villi and in the mesenteric lymph nodes.
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