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  • Title: Malignant thymoma with distant metastases: a case report and review of the literature.
    Author: Ichino Y, Obuchi M, Suko K, Ishikawa T.
    Journal: Jpn J Clin Oncol; 1983 Dec; 13(4):733-9. PubMed ID: 6685786.
    Abstract:
    A patient, a 46-year-old female, with a malignant thymoma spreading to the extrathoracic region is described. She underwent a thoracotomy and received radiation therapy, but the myasthenic symptoms did not disappear. A metastatic thymoma of the right mandibula was removed 9 months after thoracotomy. Further examination revealed metastatic thymomas of the bone and liver. After the operation the patient received combination chemotherapy (vincristine, cyclophosphamide, 6-mercaptopurine, prednisone) and remained asymptomatic for 31 months. She was found to have a metastatic thymoma in the occipital lobe of the brain 3.5 years after thoracotomy, and died from infection of the lung. Distant metastases and chemotherapy in malignant thymoma are reviewed.
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