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  • Title: Comparison of 2'-fluoro-arabinosyl pyrimidine nucleosides and 1-beta-D-arabinofuranosylcytosine on immunological parameters in vitro.
    Author: Merluzzi VJ, Last-Barney K, Fox JJ.
    Journal: Int J Immunopharmacol; 1983; 5(5):421-5. PubMed ID: 6686216.
    Abstract:
    1-beta-D-arabinofuranosylcytosine (ara C)3, 2'-fluoro-5-iodo-arabinofuranosyl-cytosine (FIAC) and 2'-fluoro-5-methyl-arabinofuranosyluracil (FMAU) were analyzed for immunosuppressive activity in vitro. In assay systems quantifying both humoral and cellular immune reactivity, FMAU and FIAC were less immunosuppressive than ara C by several orders of magnitude.
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