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  • Title: [Effect of emotional-pain stress on the activity of the gamma-aminobutyric acid system].
    Author: Andreev BV, Galust'ian GE, Ignatov IuD, Nikitina ZS, Sytinskiĭ IA.
    Journal: Ukr Biokhim Zh (1978); 1983; 55(6):652-6. PubMed ID: 6686357.
    Abstract:
    In experiments on rats the emotional-pain stress is studied for its effect on the activity of the gamma-aminobutyric acid (GABA) system in the forebrain and stem structures, on GABA catabolism and GABA metabolism-related energy metabolism indices in the hippocamp and frontal cortex neurons. It is shown that the stress effect is accompanied by the GABA level increase and GABA-transaminase inhibition with a simultaneous rise of the succinate dehydrogenase and glutamate dehydrogenase activity. The pain factor is established to be very important for changes in the activity of GABA-transaminase and succinate dehydrogenase. The found shifts in the GABA activity system are significant for neuromediatory and energy adaptation to the stress.
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