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  • Title: [Infectious activity of cell fractions isolated from the brain of mice with scrapie].
    Author: Loginova NV, Cherednichenko IuN, Viazov SO, Vanag KA, Zhdanov VM.
    Journal: Vopr Virusol; 1983; 28(5):597-601. PubMed ID: 6686393.
    Abstract:
    The agent of scrapie was found to induce clinically similar diseases in BALB/c and NIH mice but differing in the duration of the incubation period (155-180 days and 110-140 days, respectively) and pathomorphological manifestations. Differentiated examinations of a brain cell pool from mice with scrapie revealed more infectious activity not neutralized with nucleases and pronasa in membrane-free cell fractions than in fractions of slowly sedimenting membranes.
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