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  • Title: The effect of lithium, imipramine and chlorpromazine on the membrane bound enzyme phosphatidylethanolamine methyltransferase.
    Author: Ziemsen B, Agarwal DP, Hoo JJ, Goedde HW.
    Journal: Arzneimittelforschung; 1983; 33(11):1523-4. PubMed ID: 6686446.
    Abstract:
    The activity of phosphatidylethanolamine methyltransferase (PMT) in disrupted human erythrocytes and ghost cells was inhibited by lithium (Li+), imipramine and chlorpromazine. There was no inhibitory effect of the drugs in concentrations similar to the average therapeutic blood levels. Li+ exerted an inhibition on PMT activity in hemolysates at concentrations 8 times the average therapeutic level whereas chlorpromazine and imipramine showed an inhibitory effect on PMT in hemolysates at 10(3) fold their respective therapeutic serum level.
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