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  • Title: Thiosemicarbazones of 2-acetylpyridine, 2-acetylquinoline, 1- and 3-acetylisoquinoline and related compounds as inhibitors of clinically significant bacteria in vitro.
    Author: Dobek AS, Klayman DL, Dickson ET, Scovill JP, Oster CN.
    Journal: Arzneimittelforschung; 1983; 33(11):1583-91. PubMed ID: 6686454.
    Abstract:
    Antibacterial activity of 64 thiosemicarbazones of 2-acetylpyridine, 2-acetylquinoline, 1- and 3-acetylisoquinoline and related compounds was determined by testing clinical isolates of ten bacterial genera, including some which were antibiotic resistant. Minimal inhibitory concentrations (MICs) of 0.016 to 0.125 microgram/ml were obtained with 26% of the compounds for Neisseria meningitidis and 0.002 to 0.25 microgram/ml with 19% of the compounds for N. gonorrhoeae. Staphylococcus aureus was inhibited in the MIC range of 0.062 to 0.5 microgram/ml by 34% of the thiosemicarbazones, whereas 26% inhibited Streptococcus faecalis with an MIC range of 0.25 to 1.0 microgram/ml. Less antibacterial activity was shown toward the Gram-negative bacilli, i.e., Pseudomonas, Klebsiella-Enterobacter, Shigella, Escherichia coli, Serratia marcescens and Proteus.
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