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  • Title: Hemodynamic activity of different doses of sulmazole by infusion.
    Author: Mendiola-García A, Fernández-Fernández JL, Tello-Arias A, Camacho-Rivera B.
    Journal: Arzneimittelforschung; 1983; 33(11):1594-8. PubMed ID: 6686455.
    Abstract:
    By means of right heart catheterisation and thermodilution the hemodynamic response to two different doses of 2-[2-methoxy-4-(methylsulfinyl) phenyl]-1H-imidazo[4,5-b]pyridine (sulmazole, AR-L 115 BS, Vardax) (1.5 mg or 0.7 mg/min) was determined in 10 hospitalized patients with congestive cardiac insufficiency. It was found that sulmazole has a marked positive inotropic effect, increasing the cardiac output and stroke work index and decreasing the peripheral systemic and pulmonary vascular resistance, almost without altering the blood pressure values; furthermore, it reduces the right atrial pressure, the pulmonary capillary pressure and the pulmonary arterial pressure. Tolerance of sulmazole was excellent; no tachyphylaxis nor rebound reactions were observed during the 36-h period of medication.
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