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  • Title: Clones from cultured, B16 mouse-melanoma cells resistant to wheat-germ agglutinin and with altered production of mucin-type glycoproteins.
    Author: Lin LH, Stern JL, Davidson EA.
    Journal: Carbohydr Res; 1983 Jan 01; 111(2):257-71. PubMed ID: 6687562.
    Abstract:
    Several clones resistant to wheat-germ-agglutinin toxicity were isolated from B16 mouse-melanoma cells. The resistance may be explained in part by fewer binding sites for the agglutinin on the variant lines; the total, cellular sialic acid content appeared somewhat reduced. Analysis of cell glycoproteins indicated a decreased content of sialic acid in one glycoconjugate that binds to wheat-germ agglutinin and has O-linked oligosaccharides.
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