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  • Title: [Synthesis and antitumor properties of carminomycin 13-cyclohexylidenhydrazone].
    Author: Povarov LS, Bazhanov VS, Averbukh LA, Gol'dberg LE, Tarasova VE.
    Journal: Antibiotiki; 1983 Feb; 28(2):95-9. PubMed ID: 6687665.
    Abstract:
    Carminomycin 13-cyclohexylidenhydrazone (CCH) was prepared by interaction of carminomycin 13-hydrazone with cyclohexane. The antiblastomic properties of CCH were studied on mice with transplantable tumors. The preparation was administered intravenously or orally. The studies showed a high antitumor activity of CCH. When CCH was administered intravenously to mice with lymphosarcoma LIO-1, the antitumor effect selectivity of it was practically equal to that of carminomycin. When used in doses equivalent by their toxicity to those of carminomycin, CCH had practically the same inhibitory effect on sarcoma 180 as carminomycin. When used orally in doses equivalent by their toxicity to those of carminomycin, CCH was more effective than carminomycin in treatment of mice with lymphosarcoma LIO-1, sarcoma 180 and lymphadenosis NK/Ly.
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