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  • Title: Hemoglobin saitama or beta 117 (G19) His leads to Pro, a new variant causing hemolytic disease.
    Author: Ohba Y, Hasegawa Y, Amino H, Miwa S, Nakatsuji T, Hattori Y, Miyaji T.
    Journal: Hemoglobin; 1983; 7(1):47-56. PubMed ID: 6687721.
    Abstract:
    An electrophoretically silent unstable hemoglobin was found in a 23-year-old Japanese woman suffering from hemolytic anemia and jaundice. The unstable beta subunit was precipitated with p-chloromercuribenzoic acid and the globin was further purified by urea CM-52 column chromatography. Results of amino acid analysis, tryptic fingerprinting and manual Edman degradation of the abnormal beta T12B established a substitution of proline for histidine beta 117 (G19). This new abnormal hemoglobin was absent in other members of the family.
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