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  • Title: Hyaline membrane disease treated with bovine surfactant.
    Author: Smyth JA, Metcalfe IL, Duffty P, Possmayer F, Bryan MH, Enhorning G.
    Journal: Pediatrics; 1983 Jun; 71(6):913-7. PubMed ID: 6687937.
    Abstract:
    Six preterm infants with severe hyaline membrane disease requiring ventilation were treated, at a median age of 15.5 hours, with a single intratracheal bolus of a bovine surfactant suspension. Arterial oxygenation increased dramatically, and chest radiograms showed improvement after two to four hours. However, a variable degree of deterioration occurred within 24 hours. All of the infants required oxygen therapy for several weeks, and one developed severe bronchopulmonary dysplasia.
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