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  • Title: [Sulfazin in the thermoradiotherapy of experimental tumors].
    Author: Efimov ML, Vasil'eva GS, Kovalenko VR.
    Journal: Med Radiol (Mosk); 1983 Jul; 28(7):22-6. PubMed ID: 6688286.
    Abstract:
    A possibility of radiosensitization of Pliss' lymphosarcoma and tumor RS-1 by using general hyperthermia with sulfazin was studied. Subcutaneous transfusion of sulfazin to rats caused a rise of the body temperature by 2-2.5 degrees C on the 2nd day after injection with the upkeep of hyperthermia for 3 days. A combined effect of sulfazin and irradiation enhanced the retardation of growth rate of tumors and increased their regression. The lifetime of animals increased significantly. A more noticeable postradiation suppression of mitotic activity was observed.
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