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  • Title: [The influence of fluothane and hexobarbital on the cerebral cortex and spinal cord centers].
    Author: Batrak GE, Khrustalev SI, Mamchur VI.
    Journal: Farmakol Toksikol; 1978; 41(4):389-92. PubMed ID: 668863.
    Abstract:
    Tests set up on 17 cats demonstrated by using methods of evoked potentials that the reflex activity of the spinal cord centers is inhibited after introduction of 2.3 +/- 0.2 ml of fluothane, whereas the functional performance capacity of the large hemispheres cortex is suppressed following administration of 3,2 +/- 0,8 ml of the drug. The restitution of excitability and conductivity of the cortex in the post-anesthetization period proceeds at the rate 1.7 times faster than the restoration of the spinal cord centers. With deepening of the hexobarbital anesthesia complete inhibition of the spinal reflex activity supervenes after introduction of 56.3 +/- 12.3 ml/kg and that of the cortex following introduction of 115.0 +/- 23.2 ml/kg of hexobarbital.
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