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  • Title: [The effect of the polymeric quaternary ammonium salt,2,5-ionene on blood coagulation].
    Author: Efimov VS, Menshova GI, Guliaev ZhG.
    Journal: Farmakol Toksikol; 1978; 41(4):409-13. PubMed ID: 668865.
    Abstract:
    In modelling overdosages of the polymeric antagonist in cases of heparin neutralization the effect of 2.5-ionene on the blood coagulation in rabbits was considered during investigations in vivo. It is shown that even appreciable overdosages of 2.5-ionene are not attended by the effect of hypocoagulation. Shortening the plasma coagulation time according to the thromboplastic activity after Quick occurs through activation of the factor X proceeding against the background of falling activity of some other coagulation factors and comes as a result of excess 2.5-ionene in the blood. A reduced amount and lowering of the aggregation capacity of the thrombocytes are noted.
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