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  • Title: Muscle pyruvate oxidation following denervation and reinnervation.
    Author: Evans OB.
    Journal: Muscle Nerve; 1983 Oct; 6(8):557-60. PubMed ID: 6689053.
    Abstract:
    Muscle pyruvate metabolism was studied in rats following sciatic nerve crush. Control studies showed high pyruvate dehydrogenase and lipoamide dehydrogenase enzyme activity in muscle with type 1 fiber predominance (soleus) and low activities in muscle with type 2 fiber predominance (extensor digitorum longus), whereas lactate dehydrogenase was much higher in the latter. Following denervation, both muscles showed a significant reduction in pyruvate dehydrogenase enzyme activity. During reinnervation, muscle with type 2 predominance developed significantly elevated pyruvate oxidation enzyme activities.
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