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  • Title: Structural and evolutionary analysis of the two chimpanzee alpha-globin mRNAs.
    Author: Liebhaber SA, Begley KA.
    Journal: Nucleic Acids Res; 1983 Dec 20; 11(24):8915-29. PubMed ID: 6689503.
    Abstract:
    Two distinct alpha-globin mRNAs were detected in chimpanzee reticulocyte mRNA using a primer extension assay. DNA copies of these two mRNAs were cloned in the bacterial plasmid pBR322, and their sequence was determined. The two alpha-globin mRNAs have obvious structural homology to the two human alpha-globin mRNAs, alpha 1 and alpha 2. Comparison of the two chimpanzee alpha-globin mRNAs to each other and to their corresponding human counterparts revealed evidence of a recent gene conversion in the human alpha-globin complex and a marked heterogeneity in the rate of structural divergence within the alpha-globin gene.
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