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  • Title: The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4.
    Author: Bonner T, O'Brien SJ, Nash WG, Rapp UR, Morton CC, Leder P.
    Journal: Science; 1984 Jan 06; 223(4631):71-4. PubMed ID: 6691137.
    Abstract:
    Two human genes that are homologous to both the murine transforming gene (oncogene) v-raf and the chicken transforming gene v-mil have been mapped by means of human-rodent somatic cell hybrids to human chromosomes previously devoid of known oncogenes. One gene, c-raf-2, which appears to be a processed pseudogene, is located on chromosome 4. The other gene, c-raf-1, which appears to be the active gene, is located on chromosome 3 and has been regionally mapped by chromosomal in situ hybridization to 3p25. This assignment correlates with specific chromosomal abnormalities associated with certain human malignancies.
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