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  • Title: Calcium association with phosphatidylserine. Modification by cholesterol and phosphatidylcholine in monolayers and bilayers.
    Author: Gregory DP, Ginsberg L.
    Journal: Biochim Biophys Acta; 1984 Jan 11; 769(1):238-44. PubMed ID: 6691975.
    Abstract:
    We have examined the association of Ca2+ with phosphatidylserine/cholesterol and phosphatidylserine/dimyristoylphosphatidylcholine mixed monolayers using a surface radiocounting technique. No Ca2+ association with pure monolayers of the uncharged molecules was observed. The Ca2+/phosphatidylserine surface ratio was approximately 1:2 in expanded monolayers of the pure anionic lipid and in phosphatidylserine/phosphatidylcholine mixtures. An increase in surface-associated Ca2+ to a number ratio of 1:1 was observed in phosphatidylserine/cholesterol films when the mole fraction of cholesterol was raised to 0.5 and above and the phospholipid number density held constant. We interpret these findings as a prevention of intermolecular salt formation by the sterol. Further support is provided by particle electrophoresis.
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