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  • Title: [Role of lipolytic enzymes in the development of hyperlipidemia induced by administration of heterologous albumin in rabbits].
    Author: Serrano DS, Nikul'cheva NG, Soliternova IB.
    Journal: Biull Eksp Biol Med; 1984 Jan; 97(1):42-5. PubMed ID: 6692022.
    Abstract:
    Experiments on rabbits have shown hyperlipidemia to develop within the first 48 h after a single intravenous injection of bovine serum albumin (BSA, fraction V). The mean concentration of blood plasma triglycerides (TG) was considerably higher than normal (by 262% after 24 and by 625% after 48 h). The cholesterol content was also elevated (by 80 and 270%, respectively). Following 7 and 14 days the lipid concentration returned to normal. The plasma post-heparin lipoprotein lipase activity (PHP-LPL) was lower 24 h and 7 days after BSA injection and the hypotriglyceridemic effect of heparin was less pronounced. The data obtained support the hypothesis that hyperlipidemia provoked by a single intravenous injection of BSA to rabbits results from low PHP-LPL activity and possible changes in TG-rich lipoprotein substrate affinity for the enzyme.
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