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  • Title: Effect of cyclophosphamide on the immune responsiveness of jirds infected with Brugia pahangi.
    Author: Katz SP, Lammie PJ.
    Journal: Infect Immun; 1984 Feb; 43(2):753-5. PubMed ID: 6693175.
    Abstract:
    The in vitro immune responsiveness of lymphocytes from Brugia pahangi-infected jirds was examined after serial administration of cyclophosphamide (20 mg/kg). Cyclophosphamide had no effect on parasite burdens, anti-B. pahangi antibody titers, or suppressed spleen cell reactivity to B. pahangi antigens. Cyclophosphamide restored cellular responsiveness to the mitogens phytohemagglutinin, concanavalin A, and pokeweed mitogen.
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