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  • Title: The effect of a single injection of papain on growth of the limb bones of the mouse.
    Author: Johnson DR.
    Journal: Growth; 1978 Mar; 42(1):27-30. PubMed ID: 669396.
    Abstract:
    The chondrodystrophic mouse mutant stumpy (stm) shortens proximal limb bones more than distal ones and acts late in development (circa 14 days post partum). It was thought that a late disturbance in bone growth might cause more damage to epiphyses of proximal than distal bones. This was investigated using a single injection of papain on days 8, 10 and 12: shortening of proximal and distal bones was demonstrated, but was similar in all three experimental groups.
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