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  • Title: Serum thymidine kinase in vitamin B12 deficiency.
    Author: Hagberg H, Gronowitz S, Killander A, Källander C.
    Journal: Scand J Haematol; 1984 Jan; 32(1):41-5. PubMed ID: 6695149.
    Abstract:
    In DNA synthesis deoxythymidine kinase (TK) catalyses the conversion of deoxythymidine to deoxythymidine monophosphate (dTMP) via the 'salvage pathway'. Serum deoxythymidine kinase (S-TK) was measured in this study in 75 patients with vitamin B12 deficiency by a new, very sensitive method, using 125I-deoxyuridine as substrate. Elevated S-TK levels were found in those patients who had developed haemolysis and anaemia and the more advanced the disease the higher the S-TK value. Thus there was a highly significant correlation between S-TK, haemoglobin level and lactic dehydrogenase activity. These findings are consistent with the theory that elevated levels of S-TK are due to release from unstable proliferating tissue.
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