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  • Title: The malaria parasite monitored by photoacoustic spectroscopy.
    Author: Balasubramanian D, Mohan Rao C, Panijpan B.
    Journal: Science; 1984 Feb 24; 223(4638):828-30. PubMed ID: 6695185.
    Abstract:
    Noninvasive photoacoustic spectroscopy was used to study the malaria parasites Plasmodium chabaudi and Plasmodium berghei, their pigment, and ferriprotoporphyrin IX, which is a by-product of the hemoglobin that the parasite ingests. The results indicate that the pigment consists of ferriprotophorphyrin self-aggregates and a noncovalent complex of ferriprotoporphyrin and protein. Spectra of chloroquine-treated parasites reveal in situ interaction between the drug and ferriprotoporphyrin. Chloroquine-resistant parasites, readily distinguishable by this method, appear to degrade hemoglobin only partially.
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