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  • Title: Testicular atrophy of rats induced by di-2-ethylhexyl phthalate: effects of vitamin A and zinc concentrations in the testis, liver and serum.
    Author: Oishi S.
    Journal: Toxicol Lett; 1984 Jan; 20(1):75-8. PubMed ID: 6695399.
    Abstract:
    Dietary administration of di-2-ethylhexyl phthalate (DEHP, 2% in diet) for 1 week to young male Wistar rats was found to cause testicular atrophy. Zinc (Zn) concentration in the testis and liver of DEHP-treated rats was lower than that in controls. Vitamin A concentration in serum and testis was increased in DEHP-treated rats. These results suggest that testicular atrophy induced by DEHP was not due to dietary or intrinsic vitamin A deficiency.
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