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  • Title: CSF GABA levels in Parkinson's disease.
    Author: de Jong PJ, Lakke JP, Teelken AW.
    Journal: Adv Neurol; 1984; 40():427-30. PubMed ID: 6695622.
    Abstract:
    CSF levels of GABA were investigated in a group of Parkinson patients without drug treatment and a group of Parkinson patients under treatment with L-DOPA or anticholinergics. Probenecid results in an elevation of CSF GABA levels in healthy persons. The results indicate a significant decrease of GABA levels in CSF in untreated Parkinson patients. Parkinson patients treated with L-DOPA or anticholinergics show nearly normal CSF GABA levels. This may suggest that the altered GABA function in Parkinson's disease is secondary to changes in the dopamine system.
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