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  • Title: Effect of thyroxine-induced hyperthyroidism on some testicular enzymes of the pyruvate/malate cycle.
    Author: Aruldhas MM, Valivullah HM, Govindarajulu P.
    Journal: Biochim Biophys Acta; 1984 Feb 14; 797(2):143-6. PubMed ID: 6696944.
    Abstract:
    The effect of thyroxine on the specific activities of testicular enzymes of the pyruvate/malate cycle involved in lipogenesis were studied in prepubertal, pubertal and adult rats. Thyroxine (25 micrograms/100 g body weight) treatment for 1 month increased the specific activity of isocitrate dehydrogenase (NADP+) but the specific activities of ATP-citrate lyase, malate dehydrogenase and malic enzyme were inhibited. Withdrawal of thyroxine treatment from hyperthyroid rats brought back all enzyme activities to normal. The study reveals a direct, specific influence of thyroxine on different testicular enzymes of the pyruvate/malate cycle.
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