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  • Title: Evidence for cholecystokinin-like immunoreactive neurons in the rat medulla oblongata which project to the spinal cord.
    Author: Mantyh PW, Hunt SP.
    Journal: Brain Res; 1984 Jan 16; 291(1):49-54. PubMed ID: 6697184.
    Abstract:
    The distribution of cholecystokinin-like immunoreactive (CCK-LI) neurons has been mapped in the rat medulla after local and intracerebroventricular colchicine injections. CCK-positive neurons were found in the nucleus raphe magnus, nucleus raphe pallidus, nucleus raphe obscurus, nucleus paragigantocellularis pars alpha, and a population of ventral medullary neurons. Combined retrograde tracing with the fluorescent dye True Blue and indirect immunofluorescence for visualizing CCK neurons suggested that there was a CCK-LI system originating in the medulla and projecting to the spinal cord. Additional double labelling experiments established that some of these CCK-LI containing neurons also contain 5-HT.
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