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  • Title: Idiotypic network: possible explanation of seronegativity in a patient with rheumatoid arthritis.
    Author: Pasquali JL, Urlacher A, Storck D.
    Journal: Clin Exp Immunol; 1984 Feb; 55(2):281-6. PubMed ID: 6697565.
    Abstract:
    In order to explain long term seronegativity in certain patients with rheumatoid arthritis (RA), we looked for the presence of anti-idiotypic antibodies against rheumatoid factors (RFs). From a patient's serum with classical but seronegative RA, we isolated a low quantity of the IgG fraction which partially recognized polyclonal RF idiotypes. The purified Fab'2 anti-idiotypic antibodies were able to inhibit up to 48% of in vitro RF production by pokeweed mitogen stimulated lymphocytes from a patient's peripheral blood with seropositive RA. The two main conclusions of this study are: (1) this single patient with seronegative RA has serum antibodies directed against RF idiotypes and (2) these anti-idiotypic antibodies could be implicated in the generation of seronegativity.
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