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  • Title: No evidence for the involvement of histamine (H1 or H2) receptors in the hypotension and presynaptic inhibition of sympathetic nerve function caused by LY-141865 in dogs.
    Author: Sabouni M, Lokhandwala MF.
    Journal: Eur J Pharmacol; 1984 Jan 13; 97(1-2):145-9. PubMed ID: 6698108.
    Abstract:
    LY-141865, a partial ergoline, caused hypotension, bradycardia and significant impairment of cardioacceleration elicited during stimulation of cardiac sympathetic nerves. These cardiovascular actions of LY-141865 were not affected either by the H1-receptor antagonist mepyramine or the H2-receptor antagonist cimetidine. The dopamine receptor antagonist sulpiride significantly reduced the hypotensive, bradycardic and presynaptic inhibitory actions of LY-141865. These results show that while dopamine receptor activation is responsible for the hypotension and presynaptic inhibition of sympathetic nerve function caused by LY-141865, histamine (H1- or H2-) receptors do not play any role in these actions of the compound.
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