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  • Title: Alloxan-induced hyperglycemia increases progestin and androgen accumulation by isolated rabbit follicles in vitro.
    Author: YoungLai EV.
    Journal: Experientia; 1984 Mar 15; 40(3):289-91. PubMed ID: 6698190.
    Abstract:
    Follicles isolated from Alloxan-treated rabbits and incubated in vitro, accumulated more progesterone and testosterone than those from saline-treated rabbits. LH augmented the accumulation of these 2 steroids. By contrast, the estradiol response to LH stimulation by follicles from Alloxan-induced hyperglycemic rabbits was diminished when compared to follicles from saline-treated rabbits. Ovaries from hyperglycemic rabbits also appeared to have more cystic follicles.
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