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  • Title: Modulation of glucocorticoid effect in thymus of adrenalectomized-diabetic rat.
    Author: Roldán A, Castillo MB.
    Journal: Horm Metab Res; 1984 Jan; 16(1):17-21. PubMed ID: 6698489.
    Abstract:
    Cellular receptors to glucocorticoids and the effect of dexamethasone and corticosterone on 3H-uridine incorporation into the acid-insoluble fraction were studied in thymocytes from adrenalectomized-diabetic rats and adrenalectomized ones. An increase in the dissociation constant of the hormone-receptor plot was observed when adrenalectomized-diabetic animals were compared to adrenalectomized controls. Meanwhile decreasing concentrations of dexamethasone and corticosterone below receptors saturation, were less active as inhibitor of 3H-uridine incorporation into RNA by thymocytes from adrenalectomized-diabetic than from adrenalectomized ones.
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