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  • Title: [Experimental studies on the effect of perfluorochemicals in tumor irradiation].
    Author: Shinoda J, Iwai T, Hattori T, Kondo H, Sakai N, Yamada H.
    Journal: Gan No Rinsho; 1984 Jan; 30(1):53-8. PubMed ID: 6700116.
    Abstract:
    The effects of radiation therapy with Fluosol-DA on rat mammary tumors were studied. The tissue oxygen tension values of tumors in breathing mixed gas (5% carbon dioxide and 95% oxygen) with Fluosol-DA (25 ml/kg, i.v.) were significantly higher than those in room air without Fluosol-DA. The rats were divided into three groups: Group I received Fluosol-DA but no irradiation, Group II was treated with 1000 rads of irradiation using 60Co without Fluosol-DA in room air and Group III received the same irradiation and Fluosol-DA in breathing mixed gas. In the latter group we observed a prolongation of the survival time and suppression of the tumor growth.
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