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  • Title: Mechanism of aprindine induced agranulocytosis: direct toxicity on CFU-C and CFU-GEMM.
    Author: Boogaerts MA, Peters M, Peersman C, Kesteloot H, Verwilghen RL.
    Journal: Scand J Haematol; 1984 Feb; 32(2):175-8. PubMed ID: 6701462.
    Abstract:
    The in vitro bone marrow growth of 2 patients with aprindine-induced agranulocytosis was studied. Granulocyte-macrophage committed stem cell (CFU-C) growth is inhibited by aprindine in a dose dependent manner. 50% inhibition of CFU-colony growth (TD50) was seen at 5.1 and 3.4 micrograms aprindine/ml medium respectively. The TD50 of control marrow CFU-C was 3.2 micrograms/ml. 100% inhibition was seen at 16 micrograms aprindine/ml, both in patients and controls. Pluripotential stem cell growth (CFU-GEMM) in control marrow was equally inhibited in a dose dependent manner by aprindine, though to a lesser extent (TD50: 9.1 micrograms/ml) and with relative sparing of pure megakaryocyte and erythroid colonies. Co-culturing of patients marrows with their respective acute phase serum did not inhibit CFU-C growth.
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