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  • Title: Reproductive studies with the anti-inflammatory agent, piroxicam: modification of classical protocols.
    Author: Perraud J, Stadler J, Kessedjian MJ, Monro AM.
    Journal: Toxicology; 1984 Feb 14; 30(1):59-63. PubMed ID: 6701905.
    Abstract:
    Reproductive toxicology studies were conducted in rabbits and rats given piroxicam, a non-steroidal anti-inflammatory agent (NSAI), orally at 2, 5 and 10 mg/kg/day. In teratology studies there was neither drug-related embryotoxicity nor teratogenicity. As piroxicam, like other NSAI, affects parturition in rats and leads to a progressive toxicity in lactating females, standard protocols were modified: dams of the female fertility study were treated from 2 weeks prior to mating until day 6 of gestation and females of the post-natal toxicity study were treated from parturition until day 12 of lactation. No other adverse effects on reproduction, fertility and postnatal development were observed.
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