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  • Title: Thermodynamic properties of the cholesterol transfer reaction from liposomes to cytochrome P450scc: an enthalpy-entropy compensation effect.
    Author: Hsu DK, Huang YY, Kimura T.
    Journal: Biochem Biophys Res Commun; 1984 Feb 14; 118(3):877-84. PubMed ID: 6704112.
    Abstract:
    We have investigated the thermodynamic properties of the cholesterol transfer reaction from various types of liposomes to purified steroid-free cytochrome P450scc. From the results of temperature effect on the reaction, we obtained delta G+, delta H+, and delta S+ values for the reaction with various phosphatidylcholine vesicles containing different fatty acyl chains. The plots of delta H+ against delta S+, and delta G+ against delta H+ both reveal that an enthalpy-entropy compensation effect was seen in a series of phospholipid and micellar media of cholesterol. Our beta-value of 420 degrees K is unusually high among reported values for biochemical reactions.
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