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  • Title: Diphenylhydantoin extension of short-term and intermediate stages of memory.
    Author: Gibbs ME, Ng KT.
    Journal: Behav Brain Res; 1984 Feb; 11(2):103-8. PubMed ID: 6704231.
    Abstract:
    Diphenylhydantoin was shown to extend the duration of maximum availability of both short-term and intermediate memory in day-old chicks following a single trial passive avoidance learning task. Diphenylhydantoin also extended the time of susceptibility of long-term memory to inhibition by cyloheximide, suggesting that the extention of the life of intermediate memory was accompanied by a delay in long-term memory formation. Furthermore, while diphenylhydantoin counteracted amnesia induced by cycloheximide given 5 min before or immediately after learning, it had no effect on amnesia induced by cycloheximide administered 5 min or later after learning. For the latter, a second injection of diphenylhydantoin was necessary. This is consistent with the argument that the first injection of diphenylhydantoin extended the life of intermediate memory and delayed the formation of long-term memory.
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