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  • Title: [Sulpiride (stereoisomers, racemic) and dopamine: actions and interactions on renal excretion of hydro-saline].
    Author: Agnoli GC, Andreone P, Cacciari M, Garutti C, Ikonomu E, Lenzi P.
    Journal: Boll Soc Ital Biol Sper; 1984 Jan 30; 60(1):181-6. PubMed ID: 6704245.
    Abstract:
    Renal effects of Dopamine (DA, subpressor dosage 0.1 microgram X kg -1 X min -1) during hypotonic polyuria in moderate hydro-saline retention are variously modified by either d- or l-Sulpiride isomers. In the presence of d-Sulpiride, DA effects, such as an increase in diuresis, free water clearance (CH20) and kaliuresis are suppressed, while increases of saluresis and natriuresis are significantly blunted. In the presence of l-Sulpiride no changes are observed in both saluresis and natriuresis, while decreases occur in diuresis, CH20 and kaliuresis. The inhibitory DA effects on isosmotic sodium reabsorption as a percentage of sodium filtered load are prevented by either isomer as well. A possible role of ineffective renal vascular DA action can be involved in such defective tubular inhibition. However is also suggested a pharmacological blockade of proximal tubular specific DA receptors.
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